Modulatory effect of zeolite in an experimental rat model of Alzheimer's disease

Omran, Aya A; Mohamed, Eman A; Abd Elraouf, Ola M; Georgy, Gehan S; Balah, Amany I

doi:10.21608/aijpms.2022.107355.1097

Modulatory effect of zeolite in an experimental rat model of Alzheimer's disease

Document Type : Original research articles

Authors

¹ Department of Pharmacology, Egyptian Drug Authority (EDA), formerly NODCAR, Giza, Egypt.

² Department of Pharmacology and Toxicology, Faculty of Pharmacy (Girls), Al-Azhar university, Cairo, Egypt.

10.21608/aijpms.2022.107355.1097

Abstract

In our study, the potential modulatory effect of zeolite on aluminum chloride used to induce Alzheimer’s disease was investigated. Rats were divided into four groups (control group, aluminum chloride group, aluminum chloride and zeolite group, zeolite group). Aluminum chloride treatment characterized by decreasing latency for animals to step into the dark section in passive avoidance test, increasing escape latency to climb the platform and spent significantly less time in the defined part in Morris water maze test .Also, increase acetylcholinesterase content, Amyloid beta content, oxidative stress markers and inflammatory mediators, also decrease phosphorylated glycogen synthase kinase 3 beta content ,and increase free cytosolic beta catenin and brain derived neurotrophic factor content (downregulation of Wnt/ β-catenin pathway). Also, in histopathological examination shows pyknosis and degeneration in the neurons of cerebral cortex, hippocampus and striatum indicating induction of Alzheimer’s disease. On the other hand, Treatment with zeolite increases latency for animals to step to the dark section of passive avoidance test, decreasing escape latency and spent significantly more time in the defined part in Morris water maze test .Also, decrease acetylcholinesterase content, Amyloid beta content, oxidative stress markers and the release of inflammatory mediators, increase phosphorylated glycogen synthase kinase 3 beta content, and decrease cytosolic free beta catenin and brain derived neurotrophic factor content (upregulation of Wnt/ β-catenin signaling pathway) decreases pyknosis and degeneration in histopathological examination indicating zeolite attenuation of aluminum chloride induction of Alzheimer’s disease .

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