Ethno-pharmacological activity of the medicinal plant Chrysanthemum‘dante purple’

Document Type : Original research articles

Authors

1 Department of Pharmacognosy, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

2 Department of Chemistry of Natural and Microbial Products, National Research Center, Dokki, Giza, Egypt

3 Department of Tanning Materials and Leather Technology, National Research Center, Dokki, Giza, Egypt

4 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

Abstract

Six compounds were extracted from the ethyl acetate fraction of Chrysanthemum dante purple flowers for the first time, and identified as ;luteolin (1), quercetin (2), apigenin 7-O-β-D-glucopyranoside (3), luteolin 7-O-β-D-glucopyranoside (4), rutin (5) and daucosterol (6). The structures of the extracted compounds had been established by comparison of their NMR and MS data with published ones. Free radical scavenging activity of flowers compound (1), total methanolic extract and fractions and confirmed that they had potent antioxidant activity even with lower concentrations, IC50 of all tested samples was temperately low between 0.3 and 0.6 mg/ml. All samples showed also potent cholesterol reduction ability. Concerning anti-inflammatory activity, the protection provided by compound (1), (luteolin), and butanol fraction were the most potent even with the lowest concentration. Further anti-proliferative activity of all tested samples showed good anti-tumor activity even with low concentrations against human colorectal (HCT-116) and hepatic (HepG-2) cancer cells exceeding Doxorubicin and moderate antitumor activity against breast (MCF-7) cancer with no cytotoxic activity against BJ-1 human skin healthy cell-line.This could promote the use of C. dante purple flower extract for pharmacological and health purposes.

Keywords

Azhar International Journal of Pharmaceutical and Medical Sciences
Volume 3, Issue 1
January 2023
Pages 86-95

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