Voltammetric Determination of Rebamipide in the presence of its degradant in bulk, pharmaceutical preparation, and biological fluids

Document Type : Original research articles

Authors

1 Pharmaceutical Analytical Chemistry Department, Facutly of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt

2 Pharmaceutical Chemistry Department, Egyptian Drug Authority, Giza, Egypt.

Abstract

In this work, we develop, optimize and validate an electrochemical method for determining Rebamipide (REBA) using anodic differential pulse voltammetry (A-DPV) for the first time. The choice of the proper anode was determined through a comparative study between electrodes, and we found the proper one is the carbon nano-tubes that are modified with the nano form of zinc oxide electrode (ZnONP/CNT/ME). The degradant pathway of the Rebamipide was illustrated by FTIR. For the REBA quantification, we have used a 0.04M B-R buffer electrolyte solution (PH = 11.0) using the ZnONP/CNT/ME. The peak showed linearity in the range of (0.09-12.37 µg/mL), limit of detection was 0.028 µg/mL and the limit of quantification was 0.086 µg/mL. Our proposed method proved a good validation profile regarding accuracy, precision, and reproducibility in comparison to the official method. Conclusively, this work suggests the usage of a rapid, sensitive, cheap, and, most importantly, environmentally friendly protocol to determine the REBA either in the presence of its degradant, in its pharmaceutical form, or in human serum.

Keywords

Azhar International Journal of Pharmaceutical and Medical Sciences
Volume 3, Issue 2
June 2023
Pages 133-140

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