Document Type : Review Articles
Authors
1
Department of Biochemistry & Molecular Biology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
2
Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr city, Cairo, Egypt.
3
Department of Biochemistry & Molecular Biology, Faculty of pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
4
Department of Neuropsychiatry, Faculty of Medicine, Kafrelsheikh University, Egypt.
Abstract
More than 50 million people globally experience epilepsy, a spectrum of diverse brain illnesses wherein recurrent epileptic seizures are the hallmark. According to International League Against Epilepsy (ILAE) four basic forms of epilepsy are distinguished: focal, generalized, combination generalized and focal, and unknown. Epilepsy may have obvious structural, infectious, metabolic, and immunological etiologies, and its etiology appears to be mostly influenced by genetics, but in the majority of cases, no obvious etiology is found. Early connected studies have identified numerous loci which might include possible genes linked to epilepsy susceptibility, and mutational research have discovered a number of mutations in both ion channel and non-ion channel genes in idiopathic generalized epileptic patients. Such genes may generally cause epilepsy, or they may account only for different types of it. In this article we demonstrated some of these genes and its direct correlation with epilepsy and the specific type idiopathic generalized epilepsy.
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